کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4419779 | 1618951 | 2015 | 7 صفحه PDF | دانلود رایگان |
• We report cytotoxicity of ionic liquids (ILs) towards the Channel Catfish Ovary (CCO) cell line.
• The cytotoxcity data have been subjected to quantitative structure–toxicity modeling.
• The toxicity of ILs towards CCO was related to cationic shape and hydrophobicity parameters.
Within this work we evaluated the cytotoxicity towards the Channel Catfish Ovary (CCO) cell line of some imidazolium-based ionic liquids containing different functionalized and unsaturated side chains. The toxic effects were measured by the reduction of the WST-1 dye after 72 h exposure resulting in dose- and structure-dependent toxicities. The obtained data on cytotoxic effects of 14 different imidazolium ionic liquids in CCO cells, expressed as EC50 values, were used in a preliminary quantitative structure–toxicity relationship (QSTR) study employing regression- and classification-based approaches. The toxicity of ILs towards CCO was chiefly related to the shape and hydrophobicity parameters of cations. A significant influence of the quantum topological molecular similarity descriptor ellipticity (ε) of the imine bond was also observed.
Journal: Ecotoxicology and Environmental Safety - Volume 112, February 2015, Pages 22–28