کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4421773 | 1308521 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estimating low-toxic-effect concentrations in closed-system algal toxicity tests
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The no-observed-effect concentrations (NOEC) and EC10 values for 108 organic compounds were estimated, using multiple endpoints (i.e., biopopulation, growth rate, and dissolved oxygen production), from previous data obtained by a closed-system algal toxicity test (test alga: Pseudokirchneriella subcapitata). These low-toxic-effect concentrations are valuable to risk assessment of chemicals and protection of the aquatic environment as such information is quite scarce in existing toxicological databases. Furthermore, based on limited amount of available data, we found that the risk of organic toxicants to phytoplankton may be severely underestimated by existing databases, which are primarily derived by the conventional batch technique. Good correlation relationships between NOEC (or EC10) and EC50 values were established. For polar and nonpolar narcotics, quantitative structure-activity relationships (QSARs) based on hydrophobicity, and/or the lowest unoccupied molecular orbital energy (Elumo) were developed with satisfactory predictive powers. The above statistical relationships can be applied to derive a preliminary estimation for the low-toxic-effect levels for other (or new) organic compounds that has no toxicological data available.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 72, Issue 5, July 2009, Pages 1514-1522
Journal: Ecotoxicology and Environmental Safety - Volume 72, Issue 5, July 2009, Pages 1514-1522
نویسندگان
Chung Yuan Chen, Yun Ju Wang, Chao Fen Yang,