کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4422047 1308529 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The changes of serum testosterone level and hepatic microsome enzyme activity of crucian carp (Carassius carassius) exposed to a sublethal dosage of pentachlorophenol
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
The changes of serum testosterone level and hepatic microsome enzyme activity of crucian carp (Carassius carassius) exposed to a sublethal dosage of pentachlorophenol
چکیده انگلیسی

Pentachlorophenol (PCP), which was reported to be a typical persistent organic pollutant and environmental endocrine disruptor, may cause threat to aquatic species. In this study, serum testosterone concentration, activity of liver microsome ethoxyresorufin O-deethylase (EROD) and glutathione S-tranferases (GST) of crucian carp (Carassius carassius) exposed to PCP for 7 and 15 d, respectively, were examined. The results showed that testosterone concentration was induced remarkably after 7 d (P<0.05), and the testosterone concentrations in 15 d treatment crucian carp were higher than those in 7 d treatment. It was found that there were significant effects on activities of EROD and GST after crucian carp were exposed to PCP for 7 and 15 d (P<0.05), compared to the controls. EROD and GST activities increased with increase in PCP concentration and also with increase in time on exposure. The results indicated that serum testosterone, EROD and GST were sensitive endpoints to PCP. PCP may have endocrine disrupting activities and may affect the reproductive success of this species. It is possible that the changes of hepatic microsome enzyme activities may result in alterations of serum testosterone levels in crucian carp.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 71, Issue 2, October 2008, Pages 384–389
نویسندگان
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