کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4422609 1308559 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of two biomarkers (CYP450 and acetylcholinesterase) in zebra mussel for the biomonitoring of Lake Maggiore (northern Italy)
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Use of two biomarkers (CYP450 and acetylcholinesterase) in zebra mussel for the biomonitoring of Lake Maggiore (northern Italy)
چکیده انگلیسی

The use of zebra mussel Dreissena polymorpha as a bioaccumulator for lipophilic compounds is nowadays standardized, but its employment in early warning systems by the biomarker approach is much less frequent. One of the main problems with the biomarker approach is due to natural variation of abiotic factors such as temperature that influence the activity of several enzymes. In this study, we investigated the influence of this environmental parameter on the activities of two different biomarkers: acetylcholinesterase (AChE) (inhibited by organophosphorus compounds) and CYP450 (inversely influenced by planar compounds and heavy metals). We used these two biomarkers to evaluate the environmental pollution of Lake Maggiore (northern Italy). Results showed a strong AChE inhibition in mussel specimens collected in some sampling sites of the lake, indicating heavy pollution by neurotoxic compounds. We also found a twofold effect on CYP450 activity, probably due to the activating effect of planar compounds and the inhibiting effect of trace metals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 63, Issue 3, March 2006, Pages 406–412
نویسندگان
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