کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4424559 1619205 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased levels of 8-hydroxy-2′-deoxyguanosine are attributable to organophosphate pesticide exposure among young children
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Increased levels of 8-hydroxy-2′-deoxyguanosine are attributable to organophosphate pesticide exposure among young children
چکیده انگلیسی

Oxidative damage has been proposed as an important mechanism linking pesticide exposure to health effects. A study of 268 young Shanghai children was conducted to examine the relationship between organophosphate pesticide (OP) exposure and a biomarker of oxidative DNA damage. Urine samples were analyzed for five nonspecific dialkyl phosphate (DAP) metabolites [dimethyl phosphates (DMs) and diethyl phosphates (DEs)] and 8-hydroxy-2′-deoxyguanosine (8-OHdG). The creatinine-adjusted median of 8-OHdG in urine samples was 3.99 ng/mg. Increased exposure to OPs was associated with greater levels of urinary 8-OHdG [total DAPs: ß (adjusted) = 0.46 per log10 unit increase, 95% confidence interval (CI) = 0.40–0.53, p = 0.000; DMs: ß (adjusted) = 0.34, 95% CI = 0.28–0.41, p = 0.000; DEs: ß (adjusted) = 0.48, 95% CI = 0.42–0.54, p = 0.000]. Thus, the 8-OHdG biomarker is useful for increasing our understanding of the link between childhood exposure to OPs and health outcomes.


► OP exposures are thought to affect health by mechanisms related to oxidative stress.
► We assessed the correlation between OP exposure and a biomarker of oxidative stress.
► Increased exposure to OPs was associated with greater levels of urinary 8-OHdG.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 167, August 2012, Pages 110–114
نویسندگان
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