کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4425265 | 1309098 | 2011 | 7 صفحه PDF | دانلود رایگان |

Nuclear magnetic resonance (NMR) – based metabolomics has the potential to identify toxic responses of contaminants within a mixture in contaminated soil. This study evaluated the metabolic response of Eisenia fetida after exposure to an array of organic compounds to determine whether contaminant-specific responses could be identified. The compounds investigated in contact tests included: two pesticides (carbaryl and chlorpyrifos), three pharmaceuticals (carbamazephine, estrone and caffeine), two persistent organohalogens (Aroclor 1254 and PBDE 209) and two industrial compounds (nonylphenol and dimethyl phthalate). Control and contaminant-exposed metabolic profiles were distinguished using principal component analysis and potential contaminant-specific biomarkers of exposure were found for several contaminants. These results suggest that NMR-based metabolomics offers considerable promise for differentiating between the different toxic modes of action (MOA) associated with sub-lethal toxicity to earthworms.
► NMR-based earthworm metabolomic analysis of the toxic mode of action of various environmental contaminants.
► Organic chemicals with different toxic modes of action resulted in varied metabolomic responses for E. fetida.
► NMR-based metabolomics differentiates between the different modes of action associated with sub-lethal toxicity.
Journal: Environmental Pollution - Volume 159, Issue 12, December 2011, Pages 3620–3626