کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4427116 | 1309146 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
Biological impairments due to mercury discharge into the environment are now an issue of global concern. From the three forms of mercury found in aquatic ecosystems, the immunotoxic effects of mercury chloride were examined in the model animal, the blue mussel. In order to investigate the toxic potency of this chemical, three exposure regimes were carried out: chronic exposure of groups of individuals, a new protocol “in tubo” designed for sub-acute exposures of individuals, and acute exposures of target cells. Chronic exposure revealed significant immunotoxic effects after 7 days at 10â6Â M, while acute exposures showed significant inhibition of phagocytosis at 10â4Â M and 10â3Â M. In sub-acute exposures both circulating haemocytes and haemocyte mortality increased at 10â4Â M and 10â3Â M while phagocytosis and the clearance rate drew hormetic toxic effects on healthy individuals. These results suggest the use of the “in tubo” design for bivalve toxicological individual studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 153, Issue 2, May 2008, Pages 416-423
Journal: Environmental Pollution - Volume 153, Issue 2, May 2008, Pages 416-423
نویسندگان
Matthieu B. Duchemin, Michel Auffret, Nathalie Wessel, Marlène Fortier, Yves Morin, Jocelyne Pellerin, Michel Fournier,