کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4428640 1619800 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Neonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan
چکیده انگلیسی


• A cohort of pregnant women was established and followed until delivery.
• Maternal NP exposure profile throughout three trimesters was characterized.
• Maternal NP exposure in the second trimester is associated with adverse neonatal outcomes.
• Pregnant women in Taiwan showed high NP urinary level.

BackgroundNonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates.MethodsA cohort of pregnant women was established in a medical centre in northern Taiwan. Urine samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. Neonatal outcomes were evaluated immediately after delivery. A mixed-effects model using a generalised estimating equation was applied to assess the association between gestational age, maternal body weight, and maternal NP concentration throughout the three trimesters. A multivariable regression model was used to determine the association between maternal NP level in urine in each trimester and neonatal outcomes.ResultsIn total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27 μg/g, 4.21 μg/g, and 4.10 μg/g in the first, second, and third trimesters, respectively. Pregnant women whose urinary NP concentrations were above the median in the second trimester had low maternal weight gain (β = − 1.55 kg, p = 0.02) and short neonatal body length (β = − 0.47 cm, p = 0.04). Women with an above-median urinary NP concentration had an odds ratio of having a small for gestational age (SGA) neonate of 7.81 (p < 0.05).ConclusionsThis study indicates that maternal high NP exposure in the second trimester is associated with SGA, decreased foetal body length at birth, and low maternal weight gain. The effects of this endocrine-disrupting substance on pregnant women and foetuses should be a concern during gestation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 458–460, 1 August 2013, Pages 367–373
نویسندگان
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