کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4428899 1619806 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
چکیده انگلیسی

RationaleInformation on how ambient air pollution affects susceptible populations is needed to ensure protective air quality standards.ObjectivesTo estimate the effect of community-level ambient particulate matter (PM) and ozone (O3) on respiratory symptoms among primarily African-American and Latino, lower-income asthmatic children living in Detroit, Michigan and to evaluate factors associated with heterogeneity in observed health effects.MethodsA cohort of 298 children with asthma was studied prospectively from 1999 to 2002. For 14 days each season over 11 seasons, children completed a respiratory symptom diary. Simultaneously, ambient pollutant concentrations were measured at two community-level monitoring sites. Logistic regression models using generalized estimating equations were fit for each respiratory symptom in single pollutant models, looking for interactions by area or by corticosteroid use, a marker of more severe asthma. Exposures of interest were: daily concentrations of PM < 10 μm, < 2.5 μm, and between 10 and 2.5 μm in aerodynamic diameter (PM10, PM2.5, and PM10–2.5, respectively), the daily 8-hour maximum concentration of O3 (8HrPeak), and the daily 1-hour maximum concentration of O3 (1HrPeak).ResultsOutdoor PM2.5, PM10, 8HrPeak, and 1HrPeak O3 concentrations were associated with increased odds of respiratory symptoms, particularly among children using corticosteroid medication and among children living in the southwest community of Detroit. Similar patterns of associations were not seen with PM10–2.5.ConclusionsPM2.5 and O3 at levels near or below annual standard levels are associated with negative health impact in this population of asthmatic children. Variation in effects within the city of Detroit and among the subgroup using steroids emphasizes the importance of spatially refined exposure assessment and the need for further studies to elucidate mechanisms and effective risk reduction interventions.


► Children with asthma may have heterogeneous responses to air pollution.
► We examined relationships between particulate matter, ozone, and asthma symptoms.
► Impacts of air pollution were stronger among children with more severe asthma.
► Effects of air pollution also differed by location within the City of Detroit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 448, 15 March 2013, Pages 48–55
نویسندگان
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