کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4429531 | 1619826 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Reconstructing the life-time lead exposure in children using dentine in deciduous teeth Reconstructing the life-time lead exposure in children using dentine in deciduous teeth](/preview/png/4429531.png)
Data are presented to demonstrate that the circumpulpal dentine of deciduous teeth can be used to reconstruct a detailed record of childhood exposure to lead. By combining high spatial resolution laser ablation ICP-MS with dental histology, information was acquired on the concentration of lead in dentine from in utero to several years after birth, using a true time template of dentine growth. Time corrected lead analyses for pairs of deciduous molars confirmed that between-tooth variation for the same child was negligible and that meaningful exposure histories can be obtained from a single, multi-point ablation transect on longitudinal sections of individual teeth. For a laser beam of 100 μm diameter, the lead signal for each ablation point represented a time span of 42 days. Simultaneous analyses for Sr, Zn and Mg suggest that the incorporation of Pb into dentine (carbonated apatite) is most likely controlled by nanocrystal growth mechanisms. The study also highlights the importance of discriminating between primary and secondary dentine and the dangers of translating lead analyses into blood lead estimates without determining the age or duration of dentine sampled. Further work is in progress to validate deciduous teeth as blood lead biomarkers.
► Reconstruction of childhood exposure history to Pb using deciduous tooth dentine.
► Pb analyses acquired for dentine growth increments of 42 days.
► Highly correlated Pb concentration profiles for pairs of deciduous molars.
► Data for Sr, Zn and Mg provide a model for the incorporation of Pb into dentine.
Journal: Science of The Total Environment - Volume 425, 15 May 2012, Pages 214–222