کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4429805 1619833 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circulating levels of metals are related to carotid atherosclerosis in elderly
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Circulating levels of metals are related to carotid atherosclerosis in elderly
چکیده انگلیسی

The aim of this study was to investigate if blood levels of trace and/or heavy metals are related to atherosclerosis in a cross-sectional study in elderly.In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects, all aged 70), the prevalence of carotid artery plaques was recorded by ultrasound. The numbers of carotid arteries with plaques (0, 1 or 2) were recorded. Also the thickness (IMT) and gray scale (IM-GSM) of the intima-media complex were measured together with plaque echogenicity. Eleven heavy metals and trace elements were analyzed in whole blood, using inductively coupled plasma-sector field mass spectrometry.Nickel levels were related to the number of carotid arteries with plaques in an inverted U-shaped manner after multiple adjustment for gender, waist circumference, body mass index, fasting blood glucose, systolic and diastolic blood pressure, HDL and LDL cholesterol, serum triglycerides, smoking, antihypertensive treatment and statin use (p = 0.026). IM-GSM and plaque echogenicity were both inversely related to chromium in a linear fashion, and to aluminum in an inverted U-shaped manner (both p < 0.0001 for IM-GSM). The relationships between metals and IMT were modest.Circulating levels of some metals, like nickel, aluminum and chromium, were related to atherosclerotic plaques or the echogenicity of the IM-GSM and overt plaques independently of cardiovascular risk factors, including lipids.


► We examine correlation between levels of 11 metals and atherosclerosis in elderly.
► A cross-sectional study with 1016 subjects aged 70.
► Carotid artery plaques were recorded by ultrasound.
► Nickel, aluminum and chromium were related to atherosclerotic plaques.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 416, 1 February 2012, Pages 80–88
نویسندگان
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