کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4429872 1619837 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Downregulation of placental S100P is associated with cadmium exposure in Guiyu, an e-waste recycling town in China
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Downregulation of placental S100P is associated with cadmium exposure in Guiyu, an e-waste recycling town in China
چکیده انگلیسی

Excessive release of heavy metals, especially cadmium (Cd) and lead (Pb), results from primitive electronic waste (e-waste) recycling activities in Guiyu, China, and has adverse effects on the health of local infants and pregnant women. We investigated the expression of placental S100P, a Ca2+-binding protein, as a biological indicator of heavy-metal environmental pollution in pregnant women involved in these activities and constantly exposed to Cd and Pb. We included 105 pregnant women in the study: 55 from Guiyu and 50 from Shantou, an area not involved in e-waste recycling. The placental concentrations of Cd and Pb (PCCd, PCPb) after birth were measured by graphite-furnace atomic-absorption spectrometry. S100P mRNA expression was determined by semi-quantitative RT-PCR and real-time quantitative PCR. S100P protein expression was examined by western blot analysis and immunohistochemistry. The expression of metallothionein (MT), previously found upregulated after heavy metal contamination, was used for comparison. Placentas from Guiyu women showed 62.8% higher Cd concentrations, higher MT levels, and lower S100P protein levels than placentas from Shantou women. Furthermore, PCCd was negatively correlated with S100P protein expression and positively with MT expression, with no correlation between PCPb and S100P or MT expression. The PCCd-associated downregulation of S100P in placentas from Guiyu women suggests that S100P might be an effective biological indicator in the placental response to Cd toxicity in areas of e-waste recycling.


► Release of Cd and Pb from e-waste processing center Guiyu induces adverse effects on the health of infants and pregnant women.
► Placental S100P, a Ca2+-binding protein was used as a biological indicator for heavy metal.
► Placentas from Guiyu women showed higher Cd concentrations, higher MT levels, and lower S100P levels.
► The Cd concentration correlated negatively with S100P protein expression.
► S100P might be an effective biological indicator response to Cd toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 410–411, 1 December 2011, Pages 53–58
نویسندگان
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