کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4469819 1622580 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women
چکیده انگلیسی

BackgroundFor 15 months in 1981–1982, the commercial milk supply on the Hawaiian island of Oahu was contaminated with heptachlor epoxide, a metabolite of the insecticide heptachlor, resulting in gestational and/or lactational exposure to offspring of women who drank cow milk during that period.Objective: To determine whether gestational and lactational exposure to heptachlor epoxide alters reproductive function and age at puberty in men or women.Methods: 457 participants were recruited from a prior high school enrollment sampling frame of 20,000 adults born during 1981–1982 who lived on Oahu since at least first grade. Number of glasses of cow milk consumed weekly by the mother during the participant’s gestation was used as a surrogate measure of heptachlor epoxide exposure. Reproductive function measures included semen analyses; reproductive hormones or their metabolites in daily urine specimens for one menstrual cycle; serum reproductive hormone levels in both sexes; and reported ages of onset for pubertal milestones.ResultsWe observed no strong associations of heptachlor epoxide exposure during gestation and lactation with reproductive endpoints. In females, heptachlor epoxide exposure was associated with longer luteal phase length and slower drop in the ratio of estradiol to progesterone metabolites after ovulation. In males, heptachlor epoxide exposure was weakly associated with higher serum follicle stimulating hormone and luteinizing hormone concentrations, but no dose–response relationship was apparent.ConclusionsThe results provide limited evidence that gestational and lactational exposure to heptachlor epoxide, due to milk contamination on Oahu in 1981–1982, resulted in clinically significant disturbances of reproductive function in men or women.


► In 1981–1982 the milk supply on Oahu was contaminated with heptachlor epoxide.
► We modeled reproductive effects of gestational and lactational exposure to heptachlor epoxide.
► We observed limited evidence of clinically significant disturbances of reproduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 121, February 2013, Pages 84–94
نویسندگان
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