کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4469903 | 1622581 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mortality after exposure to polychlorinated biphenyls and dibenzofurans: 30 years after the “Yucheng Accident” Mortality after exposure to polychlorinated biphenyls and dibenzofurans: 30 years after the “Yucheng Accident”](/preview/png/4469903.png)
BackgroundIn 1979, approximately 2,000 people in central Taiwan were accidentally exposed to polychlorinated biphenyls and dibenzofurans due to ingestion of contaminated cooking oil. This event was called Yucheng, “oil-syndrome” in Chinese. We followed the exposed persons and compared their cause-specific mortality with that of neighborhood referents 30 years after the accident.MethodsWe obtained age- and gender-matched referents from the 1979 neighborhoods of the exposed people. Cause-specific mortality was compared between exposed subjects (N=1803) and their neighborhood referents (N=5170) using standardized mortality ratios (SMR). Total person-years for the Yucheng subjects and neighborhood referents were 48,751 and 141,774, respectively.ResultsThe SMR for all causes (SMR=1.2, 95% CI: 1.1–1.3), diseases of the circulatory system (SMR=1.3, 95% CI: 1.0–1.6), and diseases of the musculoskeletal system and connective tissue (SMR=6.4, 95% CI: 2.8–12.7) were elevated in Yucheng subjects. Among Yucheng males, the SMRs for diseases of the digestive system (SMR=1.9, 95% CI: 1.2–2.8), malignant neoplasm of stomach (SMR=3.5, 95% CI: 1.5–7.0), and malignant neoplasm of lymphatic and hematopoietic tissue (SMR=3.0, 95% CI: 1.1–6.6) were increased. The SMR for total neoplasms was increased (SMR=1.3, 95% CI: 0.9–1.7).ConclusionWe conclude that exposure to PCBs/PCDFs at levels that produced symptoms in many affects mortality patterns 3 decades after exposure.
► This cohort has been exposed to high doses of dioxin-like chemicals.
► 30 year follow-up of mortality in this cohort.
► Similar socioeconomic and geographic profiling between exposed and unexposed group.
► Because of similar demographic background, potential bias could be minimized.
► Increased mortality from several non-malignant diseases and cancer in this cohort.
Journal: Environmental Research - Volume 120, January 2013, Pages 71–75