کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4469957 1622585 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factors influencing combined exposure to three indicator polychlorinated biphenyls in an adult cohort from Bolivia
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Factors influencing combined exposure to three indicator polychlorinated biphenyls in an adult cohort from Bolivia
چکیده انگلیسی

Polychlorinated biphenyls are persistent organic pollutants that have been used for decades in several industrial applications. Although production of polychlorinated biphenyls was restricted from the 1970s in most countries, substantial amounts remain in old equipment and buildings and they have been detected in various environmental and biological matrices.The main objective of this study was to analyze predictors of the combined exposure to three non-dioxin-like polychlorinated biphenyls (congeners 138, 153 and 180) in serum and adipose tissue from an adult cohort (n=112) living in the city of Santa Cruz de la Sierra (Bolivia) and surrounding towns/villages. A second aim was to identify modifiers that might influence the statistical associations found, using crude, partially-adjusted, and global multiple linear regression models.Main predictors of serum concentrations were occupation and fatty food consumption, while those for adipose tissue concentrations included age, smoking habit, fatty food consumption, and residence. The differences between the two matrices might be derived from their biological meaning, given that adipose tissue concentrations are an indicator of chronic exposure to polychlorinated biphenyls while serum levels are a good predictor of ongoing exposure and the mobilization of polychlorinated biphenyls stored in fatty tissues. Body mass index was found to be an important modifier of these associations.


► Multivariate models were used to predict serum and adipose tissue PCB concentrations.
► Fatty food consumption was related to both serum and adipose tissue concentrations.
► Serum concentrations were also predicted by occupation.
► Predictors of adipose tissue concentrations also included age, smoking and residence.
► BMI was an important modifier of the associations found.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 116, July 2012, Pages 17–25
نویسندگان
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