Microstructural modelling of cerebral aneurysm evolution through effective stress mediated destructive remodelling

• We presented a fluid-solid-growth model for the formation of a cerebral aneurysm.
• The arterial wall was defined with the ability of degradation, growth and remodelling.
• The degradation of elastin was defined as a function of vascular effective stress.
• The model was consistent with other computational or clinical studies.
• The evolving microstructural properties of the wall were predicted.

Recently, researchers have shown an increased interest in the biomechanical modelling of cerebral aneurysm development. In the present study a fluid-solid-growth model for the formation of a fusiform aneurysm has been presented in an axi-symmetric geometry of the internal carotid artery. This model is the result of two parallel mechanisms: first, defining arterial wall as a living tissue with the ability of degradation, growth and remodelling and second, full coupling of the wall and the blood flow. Here for the first time the degradation of elastin has been defined as a function of vascular wall effective stress to take into account the shear dependent nature of degradation and the mural-cell-mediated destructive activities. The model has been stabilized in size and mechanical properties and is consistent with other computational or clinical studies. Furthermore, the evolving microstructural properties of the wall during the evolution process have been predicted.

A fluid-solid-growth model for the formation of a cerebral aneurysm is presented. The degradation of elastin was defined as a function of vascular effective stress.Figure optionsDownload as PowerPoint slide