A model of the physiological basis of a multivariate phenotype that is mediated by Ca2+ signaling and controlled by ryanodine receptor composition

► Calcium signaling is modeled as the physiological basis of a multivariate phenotype. ► The multivariate phenotype includes cardiac, skeletal muscle and neural functions. ► Predictions agree with empirical findings of the effect of RyR3 on calcium transients. ► Results illustrate how shared molecular components cause functional correlations.