کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497162 1318919 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cell state transition produces an emergent change detector
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
T cell state transition produces an emergent change detector
چکیده انگلیسی
In addition to modeling T cell activation, we also formulate a model of the proliferation of effector T cells in response to the consumption of positive growth signal, secreted throughout the T cell response. We discuss how the interaction between T cells and growth signal generates an emergent threshold detector that responds preferentially to large changes in antigen stimulation while ignoring small ones. As a final step, we discuss how the de novo generation of adaptive regulatory T cells during the latter phase of the T cell response creates a negative feedback loop that controls the duration and magnitude of the T cell response. Hence, the immune network continually adjusts to a shifting baseline of (self and non-self) antigens, and responds primarily to abrupt changes in these antigens rather than merely their presence or absence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 275, Issue 1, 21 April 2011, Pages 59-69
نویسندگان
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