کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497416 1318933 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A model for Ca2+ waves in networks of glial cells incorporating both intercellular and extracellular communication pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A model for Ca2+ waves in networks of glial cells incorporating both intercellular and extracellular communication pathways
چکیده انگلیسی
Networks of glial cells, and in particular astrocytes, are capable of sustaining calcium (Ca2+) waves both in vivo and in vitro. Experimentally, it has been shown that there are two separate modes of communication: the first by the passage of an agent (inositol 1,4,5-triphosphate, IP3) through gap junctions (GJs) joining cells; the second by the diffusion of an extracellular agent (adenosine triphosphate, ATP) that binds to receptors on the cells. In both cases, the outcome is the release of Ca2+ from internal stores in the glial cells. These two modes of communication are not mutually exclusive, but probably work in conjunction in many cases. We present a model of a two-dimensional network of glial cells that incorporates regenerative intercellular (GJ) and extracellular (ATP) pathways. In the extreme cases of only one type of pathway, the results are in agreement with previous models. Adding an extracellular pathway to the GJ model increased the extent and duration of the Ca2+ wave, but did not significantly change the speed of propagation. Conversely, adding GJs to the extracellular model did increase the wave speed. The model was modified to apply to the retina by extending it to include both astrocytes and Müller cells, with GJs the dominant coupling between astrocytes and ATP responsible for most of the remaining communication. It was found that both pathways are necessary to account for experimental results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 263, Issue 1, 7 March 2010, Pages 45-58
نویسندگان
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