Artocarpus lakoocha roxb.: An untapped bioresource of resveratrol from North East India, its extractive separation and antioxidant activity

• Extraction of resveratrol from plant species was studied.
• At optimized conditions 85,000 mg/kg resveratrol was obtained from the raw material.
• Kinetics of extraction was studied which is dependent on diffusional effect.
• Thermodynamic parameters for extraction were determined.
• Extracted compound showed antioxidant activity.

Now a day, the demand of naturally occurring biomolecules in the present society and global market is well known. Artocarpus lakoocha Roxb. is an untapped bioresource of resveratrol, a phenolic compound that is used for its anti-aging, cardioprotective and anticancer activities among many others, from North East India. This work evaluates the effect of parameters such as solvent, time, temperature, speed of agitation, solid to solvent ratio and particle size on the extraction yield of resveratrol from this bioresource. Under the optimized conditions of the process parameters stated above, 85,000 mg/kg resveratrol could be extracted from 90,000 mg/kg Artocarpus lakoocha Roxb. within 7 h using ethanol as the solvent. Extraction kinetics was estimated using two different kinetic models. The results showed that the extraction process was dependent on diffusional effect inside the sample. Thermodynamic parameters for extraction process were determined and the process was found to be spontaneous. The compound so extracted showed a significant antioxidant activity with IC50 value of 53.24 μg/ml. Thus the extracted resveratrol can be used as therapeutic agent.

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