کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4513478 | 1624857 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and bioactivity of lignin related high-added-value 2H,4H-dihydro-pyrano[2,3-c]pyrazoles and 1H,4H-dihydro-pyrano[2,3-c]pyrazoles Synthesis and bioactivity of lignin related high-added-value 2H,4H-dihydro-pyrano[2,3-c]pyrazoles and 1H,4H-dihydro-pyrano[2,3-c]pyrazoles](/preview/png/4513478.png)
• Dihydro-pyrano[2,3-c]pyrazoles were synthesized with aromatic aldehydes obtained from lignin.
• The synthesis of dihydro-pyrano[2,3-c]pyrazoles was carried out with microwave-assisted technology.
• The syringyl substituted compounds exhibited very potent antioxidant activity.
• Those compounds possessed low cytotoxicity.
• Their structure–activity relationship (SAR) was studied.
• It provided an effective approach for value-added application of lignin.
A series of novel 2H,4H-dihydro-pyrano[2,3-c]pyrazoles and 1H,4H-dihydro-pyrano-[2,3-c]pyrazoles were synthesized with aromatic aldehydes obtained from lignin and in vitro antioxidant using microwave-assisted technology and cytotoxic activities of these compounds were evaluated. The structure activity relationship (SAR) studies showed that the introduction of methoxy group in aromatic groups of dihydro-pyrano[2,3-c]pyrazoles could significantly increase their radical scavenging activities and the substituted moieties at N or C-3 position of dihydro-pyrano[2,3-c]pyrazoles could potentially influence on their antioxidant activities. Compared to positive drug control, syringyl (4-hydroxy-3,5-dimethoxyphenyl) substituted 2H,4H-dihydro-pyrano-[2,3-c]-pyrazoles 6a, 6d, 6g, 6j and 1H,4H-dihydro-pyrano-[2,3-c]pyrazoles 7a, 7d, 7g have much better antioxidant activity. In addition, all of those compounds showed low cytotoxicity through cytotoxicity evaluation. Thus, these compounds might have potential as promising agents for curing some free radical-related diseases or food additives.
High-added-value 2H,4H-dihydro-pyrano[2,3-c]pyrazoles and 1H,4H-dihydro-pyrano[2,3-c] pyrazoles were prepared from lignin and screened for their antioxidant activity. The compounds containing syringyl moiety showed very potent antioxidant activity.Figure optionsDownload as PowerPoint slide
Journal: Industrial Crops and Products - Volume 52, January 2014, Pages 413–419