کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4521654 1625195 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolomic quality control of claimed anti-malarial Artemisia afra herbal remedy and A. afra and A. annua plant extracts
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
پیش نمایش صفحه اول مقاله
Metabolomic quality control of claimed anti-malarial Artemisia afra herbal remedy and A. afra and A. annua plant extracts
چکیده انگلیسی

Malaria remains a serious health problem world wide, especially in developing countries. Recent advances in the treatment of malaria have taken place and today combination therapies containing artemisinin (isolated in 1971 from Artemisia annua) and its derivatives have become the main weapon in the fight against this disease. Many herbal companies are now trying to make use of the success of artemisinin by selling Artemisia plant material in various formulations. We have therefore decided to test the product of one such company which claims that its capsules contain artemisinin. We have used a rapid NMR targeted metabolomics approach combined with principle component analysis (PCA) to verify that the capsules are indeed A. afra and not A. annua. In addition the concentration of artemisinin in the plant material was determined with a sensitive LC–MS method. This analysis indicated that even if the company has used A. annua in their capsules the dosage of artemisinin will be far to low to be effective. Our analysis shows that NMR with PCA can be a rapid and valuable tool in the quality control of herbal supplements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: South African Journal of Botany - Volume 74, Issue 2, April 2008, Pages 186–189
نویسندگان
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