کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4752548 1361332 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research review paperRaman tags: Novel optical probes for intracellular sensing and imaging
ترجمه فارسی عنوان
مقاله پژوهشی مقاله برچسب های رامن: پروب های رؤیت نوری برای سنجش درون سلولی و تصویربرداری
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

Optical labels are needed for probing specific target molecules in complex biological systems. As a newly emerging category of tags for molecular imaging in live cells, the Raman label attracts much attention because of the rich information obtained from targeted and untargeted molecules by detecting molecular vibrations. Here, we list three types of Raman probes based on different mechanisms: Surface Enhanced Raman Scattering (SERS) probes, bioorthogonal Raman probes, and Resonance Raman (RR) probes. We review how these Raman probes work for detecting and imaging proteins, nucleic acids, lipids, and other biomolecules in vitro, within cells, or in vivo. We also summarize recent noteworthy studies, expound on the construction of every type of Raman probe and operating principle, sum up in tables typically targeting molecules for specific binding, and provide merits, drawbacks, and future prospects for the three Raman probes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 35, Issue 2, March–April 2017, Pages 168-177
نویسندگان
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