کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4753258 | 1416560 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro formation of vascular-like networks using hydrogels
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro formation of vascular-like networks using hydrogels In vitro formation of vascular-like networks using hydrogels](/preview/png/4753258.png)
چکیده انگلیسی
Tissue engineering has great potential to create tissue and organ constructs of clinically relevant sizes. The main obstacle to creating volumetric tissue constructs was the lack of a technique for fabricating dense and perfusable vascular networks in vitro within the constructs. In significant efforts to develop such a technique, hydrogels have been used as materials for templates and support architectures of vascular-like networks because of their excellent properties, such as high biocompatibility, flexibility, and the rapid diffusion of oxygen and nutrients compared with solid materials. Herein, we reviewed current hydrogel-based strategies to fabricate vascular-like networks in vitro. The first strategy was based on the ability of vascular endothelial cells to form capillary-like tubes. The second was an engineering-based strategy that can be categorized into templating, modular assembly, microfabrication, rapid prototyping technique, and their hybrid model. Finally, we discussed future directions in tissue engineering for creating transplantable and volumetric constructs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bioscience and Bioengineering - Volume 122, Issue 5, November 2016, Pages 519-527
Journal: Journal of Bioscience and Bioengineering - Volume 122, Issue 5, November 2016, Pages 519-527
نویسندگان
Takayuki Takei, Shinji Sakai, Masahiro Yoshida,