کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4755049 1418400 2017 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research advances on plectasin and its derivatives as new potential antimicrobial candidates
ترجمه فارسی عنوان
پیشرفت های تحقیق در مورد پلاکتاسیون و مشتقات آن به عنوان بالقوه نامطلوب بالقوه ضد میکروبی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Plectasin is a cationic antimicrobial peptide (AMP) that is 40 residues long and belongs to the cysteine-stabilized α-helix and β-sheet superfamily. This peptide, which was first isolated from the saprophytic fungus Pseudoplectania nigrella, exhibits strong bactericidal activity toward several gram-positive pathogens, including Staphylococcus aureus and Streptococcus pneumoniae. In this review, we discuss the latest advances made to improve plectasin antimicrobial activity and reduce its cytotoxicity, namely a variety of methods for the design and construction of plectasin derivatives, hybrids, and available expression systems. In addition, we focused on the investigations regarding the biological activity, therapeutic properties, and mechanisms of action of this promising antibiotic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 56, May 2017, Pages 62-70
نویسندگان
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