کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4763358 | 1422962 | 2017 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ozonation of antidepressant fluoxetine and its metabolite product norfluoxetine: Kinetics, intermediates and toxicity
ترجمه فارسی عنوان
استحکام فلوکستین ضد افسردگی و محصول متابولیتی آن، نورفلوکستین: سینتیک، واسطه و سمیت
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Ozonation of an antidepressant fluoxetine (FX) and its principle metabolite product norfluoxitine (NFX) were investigated. Experimental results showed that ozonation rates of FX and NFX varied strongly with pH. The kinetic constants of FX increased by 6 orders of magnitude from 3.0Â Mâ1Â sâ1 (protonated FX) to 1.7Â ÃÂ 106Â Mâ1Â sâ1 (deprotonated FX), and that of NFX increased by 5 orders of magnitude from protonated form (3.9Â Mâ1Â sâ1) to deprotonated form (3.5Â ÃÂ 105Â Mâ1Â sâ1). Nine and six transformation intermediates were observed for FX and NFX, respectively. Ozonation pathways were proposed as hydroxylation, demethylation, carbonylation and cleavage of the benzene ring. Defluorination products were detected for FX. Resemblance and differences between oxidation products of FX and NFX could help verify the pathway. Formation and removal of ozonation products were monitored at different pH. Finally, ozonation of both FX and NFX led to formation of three organic acids and three aldehydes. The constitution of organic carbon during ozonation of FX and NFX was analyzed. The analysis showed that carboxylic acids made a great contribution to TOC after 60Â min ozonation. Vibrio fischeri experiments were used to assess toxicity evolutions during ozonation. The toxicity decreased after ozonation, but cannot be fully removed. The experiments results proved that the formation of aldehyde byproducts may lead to the obstinate toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 316, 15 May 2017, Pages 951-963
Journal: Chemical Engineering Journal - Volume 316, 15 May 2017, Pages 951-963
نویسندگان
Yue Zhao, Gang Yu, Siyu Chen, Siyu Zhang, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang,