کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4769547 | 1426203 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of pH in the structure and mass transport by diffusion of theophylline
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
The influence of hydrochloric acid and sodium hydroxide on the diffusion of aqueous solutions of theophylline (TPh) has been investigated by using Taylor dispersion method to measure ternary mutual diffusion coefficients for aqueous solutions of (TPh + HCl) and (TPh + NaOH) at 25 °C. The goal of this research is to have an assessment on the effect of the pH on the transport of this drug and thus giving a better understanding on the mechanisms behind the mass transport by diffusion. This has been complemented with 1H and 13C NMR spectroscopy combined with DFT calculations allowing to confirm the presence of different species depending on the local pH, corresponding to the doubly protonated TPh (pH 2.0), singly protonated TPh (pH 3.0), and the neutral TPh base, above pH 8.8.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Chemical Thermodynamics - Volume 110, July 2017, Pages 162-170
Journal: The Journal of Chemical Thermodynamics - Volume 110, July 2017, Pages 162-170
نویسندگان
Cecilia I.A.V. Santos, M. LuÃsa Ramos, LicÃnia L.G. Justino, Hugh D. Burrows, Artur J.M. Valente, Miguel A. Esteso, Derek G. Leaist, Ana C.F. Ribeiro,