کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4788 245 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maximization of metabolite in fed-batch cultures: Sufficient conditions for singular arc and optimal feed rate profiles
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Maximization of metabolite in fed-batch cultures: Sufficient conditions for singular arc and optimal feed rate profiles
چکیده انگلیسی

Fed-batch fermentation for maximization of metabolite production at a final time is normally a singular control problem. The singular optimal feed rate strategy depends on relative position of peaks in the specific rates of cell growth μ, substrate consumption σ and product formation π. Regions in which singular feed rates exist are identified and variation of substrate concentration in the singular region is elucidated. Sufficient conditions for the existence of a singular arc are developed, which can be incorporated into an efficient and stable computational scheme to obtain the optimal feed rate profiles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 37, Issue 1, 15 October 2007, Pages 62–74
نویسندگان
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