کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4933463 | 1433789 | 2017 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased levels of serum fibroblast growth factor-2 in children with autism spectrum disorder
ترجمه فارسی عنوان
کاهش سطح فاکتور رشد فیبروبلاست سرم در کودکان مبتلا به اختلال طیف اوتیسم
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کلمات کلیدی
اختلال طیف اوتیسم، اتوپاتوژنز، عامل فیبروبلاست رشد 2، عامل فیبروبلاست پایه، توسعه قشر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The neurodevelopment and functioning of the central nervous system, and especially the cerebral cortex, have basic importance to understand neuropsychiatric disorders like autism. Fibroblast growth factor-2 (FGF-2) plays a very important role in the development and functioning of the cortex. FGF-2 is related to developmental processes in the central nervous system such as neurogenesis, migration, differentiation and survival. This study researched the serum FGF-2 levels in children with autism spectrum disorder (ASD). With this aim, 60 ASD children and 40 healthy controls were compared. We applied a sociodemographic form and the Childhood Autism Rating Scale (CARS) to each subject with their family to assess the severity of autism. Additionally, all subjects had routine laboratory tests performed. Serum samples were studied with ELISA. The results found that serum FGF-2 levels were statistically significantly low in the patient group compared to the healthy control group (p value 0.003). Additionally there was a statistically significant negative correlation identified between serum FGF-2 levels and CARS score for all subjects (r = â0.300; p = 0.02). In conclusion, FGF-2 may contribute to the etiopathogenesis of ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 257, November 2017, Pages 79-83
Journal: Psychiatry Research - Volume 257, November 2017, Pages 79-83
نویسندگان
Erman Esnafoglu, Sema Nur Ayyıldız,