کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4933776 | 1433800 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between sleep quality and inflammatory markers in patients with schizophrenia
ترجمه فارسی عنوان
ارتباط بین کیفیت خواب و نشانگرهای التهابی در بیماران مبتلا به اسکیزوفرنیا
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کلمات کلیدی
بیخوابی، استاتیک گلبول سفید خون، نسبت نوروفیل لنفوسیت، نسبت پروتئین به لنفوسیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Sleep disorder is a risk factor for several systemic inflammation-related diseases and there are extensive data showing that schizophrenia is associated with chronic low-grade systemic inflammation. This study investigated the associations between sleep quality and inflammatory markers in patients with schizophrenia, which has not been examined before. Sleep quality (total sleep time, sleep efficiency, sleep onset latency, total activity counts, wake after sleep onset, number of awakening, and average length of awakening) was measured using actigraphy in 199 schizophrenia inpatients. The state of inflammation was measured using blood concentration of white blood cells (WBC) and neutrophils, together with neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR). The results showed that total sleep time was negatively associated with NLR and PLR, and sleep efficiency was negatively associated with neutrophil counts and NLR. Sleep onset latency, total activity counts, wake after sleep onset, and number of awakening were positively associated with WBC and neutrophil counts. The average length of awakening was positively associated with NLR and PLR. This is the first report to suggest that improving sleep quality may modulate the state of inflammation in patients with schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 246, 30 December 2016, Pages 154-160
Journal: Psychiatry Research - Volume 246, 30 December 2016, Pages 154-160
نویسندگان
Shih-Hua Fang, Katsuhiko Suzuki, Chin Leong Lim, Ming-Shun Chung, Po-Wen Ku, Li-Jung Chen,