کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4933814 | 1433800 | 2016 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral adenosine levels in euthymic patients with bipolar disorder
ترجمه فارسی عنوان
سطوح آدنوزین محیطی در بیماران مبتلا به اختلال دوقطبی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Recent evidence points to the involvement of the purinergic signaling in the pathophysiology of bipolar disorder. The aim of this study was to assess the serum levels of adenosine and to evaluate its relation to functioning in 24 euthymic patients with bipolar disorder type I and in 25 matched healthy controls. Subjects were evaluated using the functioning assessment short test. Serum purine levels were measured by high pressure liquid chromatography. Our results show a decrease in serum adenosine levels in bipolar disorder patients compared with controls (t=Â â4.8, df=Â 43.96, p<0.001). Moreover, a significant negative correlation was found between patient adenosine levels and depression scale scores (r=Â â0.642, p=Â 0.001). Higher functional impairment was linked to lower levels of adenosine in patients (rho=Â â0.551, p=Â 0.008). Taken together, our results provide evidence for a purinergic imbalance in bipolar disorder, specifically an adenosinergic dysfunction. Our results also indicate a relation between adenosine levels and the functional impairment caused by the disorder, which could demonstrate a potential relation of adenosine levels in worsening of symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 246, 30 December 2016, Pages 421-426
Journal: Psychiatry Research - Volume 246, 30 December 2016, Pages 421-426
نویسندگان
Carolina Gubert, Cesar Eduardo Jacintho Moritz, Mirela Paiva Vasconcelos-Moreno, Bárbara Tietböhl Martins Quadros dos Santos, Juliana Sartori, Adam Fijtman, Márcia Kauer-Sant'Anna, Flávio Kapczinski, Ana Maria Oliveira Battastini,