کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4933877 | 1433884 | 2017 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study
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کلمات کلیدی
Bipolar I disorder - اختلال Bipolar INeuroimaging - تصویربرداری عصبیventrolateral prefrontal cortex - قشر prefrontal قاعده درونی ventrolateraldorsomedial prefrontal cortex - قشر پیش از افسردگی پس از زایمانreward circuit - مدار پاداشvoxel-based morphometry - مورفومتری مبتنی بر واکسلventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 269, 30 November 2017, Pages 82-89
Journal: Psychiatry Research: Neuroimaging - Volume 269, 30 November 2017, Pages 82-89
نویسندگان
Junyong Lee, Sunyoung Choi, June Kang, Eunsoo Won, Woo-Suk Tae, Min-Soo Lee, Byung-Joo Ham,