کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4933941 1433890 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cortical complexity in bipolar disorder applying a spherical harmonics approach
ترجمه فارسی عنوان
پیچیدگی قشر در اختلال دوقطبی با استفاده از یک روش هارمونیک کروی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
Recent studies using surface-based morphometry of structural magnetic resonance imaging data have suggested that some changes in bipolar disorder (BP) might be neurodevelopmental in origin. We applied a novel analysis of cortical complexity based on fractal dimensions in high-resolution structural MRI scans of 18 bipolar disorder patients and 26 healthy controls. Our region-of-interest based analysis revealed increases in fractal dimensions (in patients relative to controls) in left lateral orbitofrontal cortex and right precuneus, and decreases in right caudal middle frontal, entorhinal cortex, and right pars orbitalis, and left fusiform and posterior cingulate cortices. While our analysis is preliminary, it suggests that early neurodevelopmental pathologies might contribute to bipolar disorder, possibly through genetic mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 263, 30 May 2017, Pages 44-47
نویسندگان
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