کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4934051 | 1433897 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional abnormalities of the right posterior insula are related to the altered self-experience in schizophrenia
ترجمه فارسی عنوان
اختلالات عملکردی عصب راست خلفی مربوط به خود تجربه شده در اسکیزوفرنی است
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کلمات کلیدی
انسولا، جنون جوانی، خوشه بندی اتصال به عملکرد خود تجربه،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The insula is involved in detecting the salience of internal and external stimuli, and it plays a critical role in psychosis. Previous studies have demonstrated the structural and functional alterations of the insula in schizophrenia. To acquire a full picture of the functional alterations of the insula in schizophrenia, the resting-state fMRI data of 46 patients with schizophrenia and 46 healthy control subjects were collected. We used clustering analysis to divide the insula into three subregions: the dorsal anterior insula (dAI), ventral anterior insula (vAI) and posterior insula (PI). Then, whole-brain functional connectivity analysis was conducted based on these subregions. The results showed that the right dAI and PI in patients exhibited altered functional connections with the primary sensorimotor area. In addition, the right PI of the patients exhibited increased functional correlations with the thalamus. More importantly, the altered functional properties of the right PI were significantly correlated with the severity of the delusion and poor insight in schizophrenia. The results suggested that the right PI might play an important role in self-experience processing in schizophrenia. Accordingly, the right PI should be considered very important in the pathological mechanism of schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 256, 30 October 2016, Pages 26-32
Journal: Psychiatry Research: Neuroimaging - Volume 256, 30 October 2016, Pages 26-32
نویسندگان
Xi Chen, Mingjun Duan, Hui He, Mi Yang, Benjamin Klugah-Brown, Hao Xu, Yongxiu Lai, Cheng Luo, Dezhong Yao,