کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4934188 1433958 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationDistinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice
ترجمه فارسی عنوان
ارتباط کوتاه ارتباط صحیح آنتاگونیست گیرنده های استروژن با تشخیص و حافظه فضایی در موش های تخمدان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Examined effects of ERα and ERβ antagonists on memory consolidation in female mice.
- Hippocampal ERα antagonism impaired spatial, but not object recognition, memory.
- Hippocampal ERβ antagonism impaired both types of memory.
- Shows memory-specific role of classical ERs in hippocampal memory consolidation.
- Supports a key role for de novo hippocampal estradiol synthesis in memory formation.

Exogenous treatment with the potent estrogen 17β-estradiol (E2) or selective estrogen receptor α/β (ERα/β) agonists enhances the consolidation of hippocampal-dependent object recognition (OR) and object placement (OP) memories in ovariectomized rodents. Although such data suggest that individual ERs are sufficient for memory consolidation, the necessity of a given ER for memory consolidation can only be demonstrated by blocking receptor function, for example with an ER antagonist. However, the effects on memory of antagonizing ERα or ERβ function are not well understood. Moreover, ER antagonism in ovariectomized subjects also provides indirect information about the role of individual ERs in the memory-enhancing effects of local hippocampal E2 synthesis. Therefore, this study used pharmacological inhibition of ERα and ERβ to elucidate the importance of each ER to memory consolidation. Specifically, we examined effects on OR and OP memory consolidation of immediate post-training dorsal hippocampal (DH) infusion of MPP and PHTPP, selective antagonists for ERα and ERβ, respectively. Each drug exhibited a distinct effect on OR and OP. DH infusion of MPP (0.28 or 2.78 ng/hemisphere) impaired memory in OP, but not OR. However, DH infusion of PHTPP (0.21 or 2.12 ng/hemisphere) impaired memory in both OR and OP. Neither drug affected the elapsed time to accumulate object exploration in either task, suggesting a specific effect on memory. These results indicate that activation of either classical ER within the dorsal hippocampus is important for hippocampal memory consolidation in ovariectomized mice, but suggest that specific ER involvement is memory- or task-specific. The findings also indirectly support a role for ERα and ERβ in mediating the memory-enhancing effects of hippocampally-synthesized E2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 85, November 2017, Pages 110-114
نویسندگان
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