Palladium-catalyzed efficient Suzuki–Miyaura reaction of potassium aryltrifluoroborates in water

• Suzuki–Miyaura reaction of potassium aryltrifluoroborates in pure water
• (i-Pr)2NH promotes the cross-coupling efficiently.
• This protocol provides a gram scale preparation of 2-cyano-4′-methylbiphenyl.
• The products could be isolated by simple filtration and recrystallization.

An efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates with (hetero)aryl halides in water without any additive. This method allows the preparation of a variety of biaryls and heterobiaryls in excellent yields. In addition, the cross-coupling product can be isolated in good yields and high purity by simple filtration and recrystallization as the reaction was performed on gram scale.

An efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates and (hetero)aryl halides in water without any additives.Figure optionsDownload as PowerPoint slide