Au(I)-catalyzed domino intramolecular cyclization for the synthesis of 2,4-disubstituted pyrimidines

• Au-catalyzed domino reactions
• An efficient route for synthesis of 2,4-disubstituted pyrimidines
• Formation of C–C and C–N bond via intramolecular cyclization

An efficient Au-catalyzed domino intramolecular cyclization reaction has been developed for the construction of pyrimidine derivatives from ynals and amidines at room temperature for 3 h. This transformation provides a new method for the formation of C–C and C–N bonds via intramolecular cyclization.

Figure optionsDownload as PowerPoint slide