Magnetic nano Fe3O4 and CuFe2O4 as heterogeneous catalysts: A green method for the stereo- and regioselective reactions of epoxides with indoles/pyrroles

In this paper, we report a new solvent-free catalytic method using the magnetic nano Fe3O4 and CuFe2O4 as competent heterogeneous catalysts for the stereo- and regioselective reactions of epoxides with indoles/pyrroles, which gave the C-alkylated indoles/pyrroles. Chiral epoxides gave the alkylated indoles with a complete inversion of stereochemistry.

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► Magnetic Fe3O4 and CuFe2O4 nanoparticles as competent heterogeneous catalysts.
► Highly stereo-, regioselective reaction of epoxides with indoles and pyrroles.
► Chiral epoxides gave the C-alkylated indoles with complete inversion.
► Solvent-free reaction conditions, simple work-up and green protocol.
► Fe3O4 and CuFe2O4 nanoparticles are recoverable and recyclable catalysts.