کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5030906 | 1470934 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative ratiometric phosphorescence hypoxia-sensing nanoprobes based on quantum dots/Ir(III) glycerol monoolein cubic-phase nanoparticles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel protocol is developed to prepare quantum dot (QD)/Ir(III) complex glycerol monoolein (GMO) cubic-phase nanoparticles (Qd/Ir GMCPNPs) as hypoxia nanoprobes, in which hypoxia probe Tris [1-phenylisoquinoline-C2, N] Iridium(III) [Ir(piq)3] and the reference QDs are separately loaded at hydrophilic and hydrophobic channels to avoid interference. Qd/Ir GMCPNPs were nearly spherical in shape, with an average size of 20-30Â nm. Their phosphorescence spectra showed that nanoprobes have a wide excited wave length range of 360-500Â nm, which is suitable for different types of measurement instruments. When the oxygen content decreased from 21% to 1%, the luminescent intensity ratio of Qd/Ir GMCPNPs in the solution and cells increased 4-fold and 2.8-fold, respectively, with an acceptable linear relationship. Particularly, extensive preliminary quantitative ratiometric oxygen sensing and long tumor imaging monitoring can be achieved with these nanoprobes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 98, 15 December 2017, Pages 119-125
Journal: Biosensors and Bioelectronics - Volume 98, 15 December 2017, Pages 119-125
نویسندگان
Jiajun Liu, Youshen Wu, Yao Yu, Ke Li, Yuanyuan Ji, Daocheng Wu,