کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5031184 | 1470941 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring
ترجمه فارسی عنوان
سنسورهای صوتی میکرو الکترومکانیکی برای نظارت بر انعقاد پلاسما و کل خون
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کلمات کلیدی
رزوناتور آکوستیک، رزوناتور آکوستیک انبساط فیلم، انعقاد خون، سیستم میکرو الکترومکانیکی، حسگر ویسکوزیته،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9 GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1 μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R2=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 91, 15 May 2017, Pages 465-471
Journal: Biosensors and Bioelectronics - Volume 91, 15 May 2017, Pages 465-471
نویسندگان
Da Chen, Shuren Song, Jilong Ma, Zhen Zhang, Peng Wang, Weihui Liu, Qiuquan Guo,