کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5031419 1470943 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus
ترجمه فارسی عنوان
اولین استفاده از دستگاه مانیتورینگ گلوکز تک پورت اپتیکال در بیماران مبتلا به دیابت نوع 1
کلمات کلیدی
نظارت مستمر گلوکز، سیستم یکپارچه حسگر نوری گلوکز، دیابت نوع 1، فلورسیم فاز، لوزالمعده مصنوعی،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The combination of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion can be used to improve the treatment of patients with diabetes. The aim of this study was to advance an existing preclinical single-port system for clinical application by integrating the sensors of a phosphorescence based CGM system into a standard insulin infusion set. The extracorporeal optical phase fluorimeter was miniaturised and is now comparable with commercial CGM systems regarding size, weight and wear comfort. Sensor chemistry was adapted to improve the adhesion of the sensor elements on the insulin infusion set. In-vitro tests showed a linear correlation of R2=0.998 between sensor values and reference glucose values in the range of 0-300 mg/dl. Electrical and cytotoxicity tests showed no negative impact on human health. Two single-port devices were tested in each of 12 patients with type 1 diabetes mellitus in a clinical set-up for 12 h. Without additional data processing, the overall median absolute relative difference (median ARD) was 22.5%. For some of the used devices the median ARD was even well below 10%. The present results show that individual glucose sensors performance of the single-port system is comparable with commercial CGM systems but further improvements are needed. The new system offers a high extent of safety and usability by combining insulin infusion and continuous glucose measurement in a single-port system which could become a central element in an artificial pancreas for an improved treatment of patients with type 1 diabetes mellitus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 88, 15 February 2017, Pages 240-248
نویسندگان
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