کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5032652 | 1471127 | 2017 | 6 صفحه PDF | دانلود رایگان |

- Poor interfacial binding between thrombus and device is a major contributing factor to distal embolization in mechanical thrombectomy.
- Radio frequency (rf) treatment is shown to have improved thrombus-device binding.
- Wire pull tests showed rf-treatment reduced thrombus slippage from 90% to less than 10%, and increased fracture energy density by 40 times.
- Significant enhancement in thrombus-device binding with rf-treatment reduces distal embolization in mechanical thrombectomy.
Intra-arterial mechanical thrombectomy (IAMT) treatments for ischemic stroke have higher recanalization rate, longer treatment time window and lower risk of symptomatic intracerebral hemorrhage (sICH). However, distal embolization may occur because of loose fragments produced during maceration and engagement. The naturally coagulated thrombus is fragile and has poor binding with thrombectomy device. Improvement of thrombus-device binding can reduce fragments breaking loose during wire pull and enhance protein crosslinking in the thrombus that can increase fragmentation resistance. The effects of in-situ applied radio frequency (rf) treatment on thrombus-wire binding and interfacial fracture have been examined in this study using wire pull tests that are mechanically analogous to the embolus retrieval method in thrombectomy. Wire inserted into a thrombus was pull tested after rf-treatment. Pull test results showed that rf-treatment improves binding and reduces thrombus slippage from over 90% to less than 10%. Fracture pull test results also showed that fracture energy density of thrombus-device interface increased 40X after rf-treatment. The dramatic increase in resistance against fracture suggests that the use of in-situ rf-treatment is a promising treatment addition to reduce distal embolization and improve clinical outcomes in mechanical thrombectomy.
Journal: Medical Engineering & Physics - Volume 47, September 2017, Pages 184-189