کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5032894 | 1370001 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To design gold nanoparticles with high contrast in optical coherence tomography (OCT), shape, size and surface charge were considered. Gold nanodisks have higher scattering efficiencies and resonant wavelength can be modulated by changing size. Negative zeta potential of bare gold facilitates diffusion in the vitreous. As a result, 160-nm-sized bare gold nanodisks exhibiting resonant wavelength at 830 nm where the source of light utilized by OCT lies were fabricated. Intravitreally injected gold nanodisks showed strong signal intensity in in vivo OCT and could attenuate retinal neovascularization of oxygen-induced retinopathy mice. They were cleared by 2 weeks without any unbearable toxicity.174
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 13, Issue 6, August 2017, Pages 1901-1911
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 13, Issue 6, August 2017, Pages 1901-1911
نویسندگان
Hyun Beom MD, Jung-Sub PhD, Dong Hyun MD, Jin Hyoung PhD, Sang-Won PhD, Tae Geol PhD, Jeong Hun MD, PhD,