Schwann cells and neurite outgrowth from embryonic dorsal root ganglions are highly mechanosensitive

Schwann cells and neurite outgrowth from embryonic dorsal root ganglions respond strongly to changes in the stiffness of their immediate surroundings in the peripheral nervous system (PNS). Mechanosensitivity is therefore crucial for the development and maintenance of the PNS. Consequently, it opens exciting new avenues to advance the field of nerve grafts for peripheral nerve repair.215