A specific spectral signature of serum and plasma-derived extracellular vesicles for cancer screening

Infrared (IR) and Raman spectroscopy were applied for a comprehensive characterization of different fractions of extracellular vesicles (EV) isolated from the serum and plasma of cancer vs non-cancer patients and healthy donors. A cancer-specific EV signature that allows to distinguish between blood samples taken from patients with cancer and samples taken from patients with other diseases, e.g. benign hypoplasia, or healthy individuals were established and successfully tested as a new diagnostics approach in nanomedicine.115