Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study

Polymeric nanoparticles of amphiphilic N-vinylpyrrolidone polymers were prepared as novel carriers of indomethacin. Their spherical morphology is less than 100 nm in size, with high indomethacin contents (up to 35%) and high drug loading efficiencies (up to 95%). The indomethacin-loaded polymeric nanoparticles showed higher cell viability compared to that of free indomethacin, the median LD50 values were 55-70 mg/kg body weight in mice and rats. These novel amphiphilic poly-N-vinylpyrrolidone nanoparticles can be used as potential carriers for new, highly efficient, injectable drug delivery systems.196