Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution

CUR-NS of larger particle size displayed higher in vitro cellular internalization and cytotoxicity. CUR solution and all three different sized CUR-NS reached the highest concentrations in the lung, followed by the liver and the spleen; and the lowest concentration was observed in the brain after i.v. administration in mice.193