From solvent-free microspheres to bioactive gradient scaffolds

In the present study, we introduce an emulsification method to prepare solvent-free microspheres of PLA using TiO2 nanoparticles as particulate emulsifier. A modified microsphere sintering method is also presented in order to fabricate porous tissue engineering scaffolds with controlled pore size. Both immersion in Simulated Body Fluid and osteoblast culture show progressive calcium phosphate mineralization on the scaffolds.195