Layer-by-layer self-assembled multilayers on PEEK implants improve osseointegration in an osteoporosis rabbit model

Despite being currently used in spine and craniofacial surgeries, Polyetheretherketone (PEEK) is usually considered as a bio-inert material. Nanoscale PAH/PSS multilayers on the surface of PEEK, which were fabricated by LbL self-assembly, improved cell adhesion, viability, and proliferation in vitro. In vivo, enhanced osseointegration of 20-layer PEEK was observed in osteoporosis rabbit model. This work highlights layer-by-layer self-assembly as a practical alternative to construct bio-active PEEK implants for efficient osseointegration.158