کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5033210 | 1370009 | 2016 | 13 صفحه PDF | دانلود رایگان |
Conventional photodynamic therapy has shown to be beneficial in the treatment of a variety of tumors. However, one of its major limitations is the inadequate penetration depth of visible light. In order to overcome this constraint, we developed 80Â nm poly-methylmethacrylate core-shell fluorescent nanoparticles (FNP) loaded with the photosensitizer tetrasulfonated aluminum phthalocyanine (Ptl). To demonstrate the efficacy of our Ptl@FNP we performed in vitro and in vivo studies using a human prostate tumor model. Our data reveal that Ptl@FNP are internalized by tumor cells, favour Ptl intracellular accumulation, and efficiently trigger cell death through the generation of ROS upon irradiation with 680Â nm light. When directly injected into tumors intramuscularly induced in SCID mice, Ptl@FNP upon irradiation significantly reduce tumor growth with higher efficiency than the bare Ptl. Collectively, these results demonstrate that the newly developed nanoparticles may be utilized as a delivery system for antitumor phototherapy in solid cancers.
The efficacy of novel phthalocyanine-loaded nanoparticles (Ptl@FNP) was tested in a human prostate tumor animal model. Near-infrared light irradiation of Ptl@FNP intratumorally injected significantly reduces tumor growth.169
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 12, Issue 7, October 2016, Pages 1885-1897